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Expression of the NUP153 and YWHAB genes from their canonical promoters and alternative promoters of the LINE-1 retrotransposon in the placenta of the first trimester of pregnancy.
Demeneva VV, Tolmacheva EN, Nikitina TV, Sazhenova EA, Yuriev SY, Makhmutkhodzhaev AS, Zuev AS, Filatova SA, Dmitriev AE, Darkova YA, Nazarenko LP, Lebedev IN, Vasilyev SA. Demeneva VV, et al. Vavilovskii Zhurnal Genet Selektsii. 2023 Mar;27(1):63-71. doi: 10.18699/VJGB-23-09. Vavilovskii Zhurnal Genet Selektsii. 2023. PMID: 36923475 Free PMC article.
The expression level of NUP153 and YWHAB from canonical promoters was higher in the group of spontaneous abortions with monosomy X compared to all other groups (p <0.05). The LINE-1 methylation index negatively correlated with the level of gene expression from both cano …
The expression level of NUP153 and YWHAB from canonical promoters was higher in the group of spontaneous abortions with monosomy X co …
Tissue differences in the exosomal/small extracellular vesicle proteome and their potential as indicators of altered tissue metabolism.
Garcia-Martin R, Brandao BB, Thomou T, Altindis E, Kahn CR. Garcia-Martin R, et al. Cell Rep. 2022 Jan 18;38(3):110277. doi: 10.1016/j.celrep.2021.110277. Cell Rep. 2022. PMID: 35045290 Free PMC article.
While classical sEV markers such as CD9/CD63/CD81 vary markedly in abundance, we identify six sEV markers (ENO1, GPI, HSPA5, YWHAB, CSF1R, and CNTN1) that are similarly abundant in sEVs of all cell types. ...
While classical sEV markers such as CD9/CD63/CD81 vary markedly in abundance, we identify six sEV markers (ENO1, GPI, HSPA5, YWHAB, C …
Transcriptomics and Proteomics Approach for the Identification of Altered Blood microRNAs and Plasma Proteins in Parkinson's Disease.
Yadav SK, Jauhari A, Singh N, Pandey A, Sarkar S, Pandey S, Garg RK, Parmar D, Yadav S. Yadav SK, et al. Cell Mol Neurobiol. 2023 Oct;43(7):3527-3553. doi: 10.1007/s10571-023-01362-4. Epub 2023 May 23. Cell Mol Neurobiol. 2023. PMID: 37219663
In vitro studies have identified the role of miR-186-5p in regulating the levels of the YWHAZ/YWHAB & CALM2 gene, which has shown maximum downregulation in PD patients and is known for its role in neuroprotection from apoptotic cell death & calcium regulation. In c …
In vitro studies have identified the role of miR-186-5p in regulating the levels of the YWHAZ/YWHAB & CALM2 gene, which has shown …
Analyzation of the Peripheral Blood Mononuclear Cells Atlas and Cell Communication of Rheumatoid Arthritis Patients Based on Single-Cell RNA-Seq.
Song X, Zhang Y, Zhao L, Fan J, Peng T, Ma Y, Guo N, Wang X, Liu X, Liu Z, Wang L. Song X, et al. J Immunol Res. 2023 Aug 12;2023:6300633. doi: 10.1155/2023/6300633. eCollection 2023. J Immunol Res. 2023. PMID: 37600067 Free PMC article.
BACKGROUND: Rheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disease with a multifactorial etiology. Peripheral blood is the main channel of the immune system, and peripheral blood mononuclear cells (PBMCs) are the immune cells that initiate the …
BACKGROUND: Rheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disease with a multifactorial etiology. Peripheral bloo …
The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1.
Ji L, Wang Q, Liu M, Zhu C, Xiao Y, Han J, Fang Y, Ye J, Yin J, Wei L. Ji L, et al. FEBS Lett. 2021 May;595(9):1275-1288. doi: 10.1002/1873-3468.14063. Epub 2021 Mar 21. FEBS Lett. 2021. PMID: 33641163 Free article.
Glucagon antagonism has been reported as a new therapeutic approach to hyperglycaemia. As the 14-3-3 protein YWHAB has been identified as a regulator of the glucagon receptor (GCGR) by affinity purification and mass spectrometry, we examined the role of YWHAB in viv …
Glucagon antagonism has been reported as a new therapeutic approach to hyperglycaemia. As the 14-3-3 protein YWHAB has been identifie …
Breast cancer cell secretome analysis to decipher miRNA regulating the tumor microenvironment and discover potential biomarkers.
Feser R, Opperman RM, Nault B, Maiti S, Chen VC, Majumder M. Feser R, et al. Heliyon. 2023 Apr 14;9(4):e15421. doi: 10.1016/j.heliyon.2023.e15421. eCollection 2023 Apr. Heliyon. 2023. PMID: 37128318 Free PMC article.
A stronger correlation between miRNA clusters and upregulated secretory markers gene expression was found in the luminal A tumor subtype. YWHAB, SFN, and MYL6B are upregulated in breast cancer patient's blood, showing biomarker potential. ...Also, these markers show …
A stronger correlation between miRNA clusters and upregulated secretory markers gene expression was found in the luminal A tumor subtype. …
Proteomic analysis revealed the pharmacological mechanism of Xueshuantong injection in preventing early acute myocardial infarction injury.
Wang A, Li Y, Wang Z, Xin G, You Y, Sun M, Miao L, Li L, Pan Y, Liu J. Wang A, et al. Front Pharmacol. 2022 Dec 21;13:1010079. doi: 10.3389/fphar.2022.1010079. eCollection 2022. Front Pharmacol. 2022. PMID: 36618918 Free PMC article.
Xueshuantong injection (XST) is mainly composed of Panax notoginseng saponins, which can dilate blood vessels and improve blood circulation, and is clinically used in the treatment of cardiovascular and cerebrovascular diseases. ...Conclusion: Xueshuantong injection …
Xueshuantong injection (XST) is mainly composed of Panax notoginseng saponins, which can dilate blood vessels and improve blood …
Exosomal miRNA-profiling of pleural effusion in lung adenocarcinoma and tuberculosis.
Zhang X, Bao L, Yu G, Wang H. Zhang X, et al. Front Surg. 2023 Jan 6;9:1050242. doi: 10.3389/fsurg.2022.1050242. eCollection 2022. Front Surg. 2023. PMID: 36684253 Free PMC article.
According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, the exosomal miRNAs target genes were mainly involved in Fc gamma R-mediated phagocytosis, Rap1 signaling pathway, and breast cancer. The hub genes, including ITGAM, FOXO1, MAPK14, YWH …
According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, the exosomal miRNAs target genes were mainly in …
Proteomics profiles of blood glucose-related proteins involved in a Chinese longevity cohort.
Zhang R, Liu F, Ye S, Du X, Ma L, Cao H, Wang Z, Li C. Zhang R, et al. Clin Proteomics. 2022 Dec 3;19(1):45. doi: 10.1186/s12014-022-09382-w. Clin Proteomics. 2022. PMID: 36463101 Free PMC article.
BACKGROUND: High blood glucose level is one of the main characteristics of diabetes mellitus. ...CONCLUSIONS: This study not only highlighted carbohydrate metabolism, PI3K-Akt pathway, glucagon signaling pathway and inflammatory response may play important roles in bloo …
BACKGROUND: High blood glucose level is one of the main characteristics of diabetes mellitus. ...CONCLUSIONS: This study not only hig …
32 results